Study Shows Your Bones Regulate Blood Sugar and Weight

Updated: May 10, 2024

Measuring waist with measuring tape

A new study by a team of international scientists has discovered that your skeleton is not simply an inert calcified structure, but plays a crucial role in controlling weight gain, energy balance, and sugar metabolism. (1) These findings indicate that all along your bones have been a card carrying member of the endocrine system – information that could lead to new ways to treat and prevent type 2 diabetes. As well, it greatly adds to our understanding of metabolism, and your skeleton’s increased importance.

The study published in the journal Cell used laboratory mice and was conducted by researchers in the U.S., Korea, France, the U.K., and Canada.

Dr. Gerard Karsenty, senior author, Paul Marks Professor in the Basic Sciences and chair of the department of Genetics and Development at Columbia University Medical Center, explains:

“The discovery that our bones are responsible for regulating blood sugar in ways that were not known before completely changes our understanding of the function of the skeleton and uncovers a crucial aspect of energy metabolism.”

The researchers had a suspicion that bone might be involved in metabolism because of leptin, a hormone released by fat cells, plays a key role in bone formation. So they started to look for other molecules hoping to find ones communicating between the endocrine system and bone forming cells.

blood algae image

In the mice, they found previously unknown metabolic processes whereby osteocalcin (a hormone that regulates mineralization and is released into bone forming cells called osteoblasts) also regulates the deposition of fat and glucose (blood sugar).

The scientists were able to prevent the development of type 2 diabetes and obesity in the laboratory mice by increasing osteocalcin!

Most likely not coincidental is the fact that patients with type 2 diabetes tend to have low levels of osteocalcin. So researchers are understandably excited by the possibility that increasing levels of osteocalcin in these patients could be a promising treatment route.

When the scientists analyzed mice that lacked osteocalcin, they found they had type 2 diabetes, more fat deposits, less adiponectin expression (the protein that helps regulate fat deposits), less insulin, and a much lower count of beta cells in the pancreas than mice with osteocalcin.

As well the research team was surprised to find that our skeletons send signals that control endocrine processes in the pancreas.

The research is groundbreaking because osteocalcin was thought to be only involved in bone building. But now we know it plays a second pivotal role in the endocrine system by increasing sensitivity to insulin and increasing secretion of insulin. It raises production of pancreatic beta cells that make insulin and reduces fat by intermingling with fat cells.

Karsenty concluded that:

“By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis, this study expands the biological importance of this organ and our understanding of energy metabolism.”

algaecal plant calcium

Increase Osteoblasts to Increase Osteocalcin

Osteocalcin is released in bone forming cells called osteoblasts. So increasing production of the latter increases production of the former. But how and why do osteoblast cells increase?

Strontium, a mineral that is # 38 on the periodic table is being used for its effectiveness against bone loss as it increases the production of osteoblast cells, without increasing osteoclast cells that tear down bone. (2)

Certain marine algaes that are high in calcium, magnesium and a range of trace minerals also have been shown to increase osteoblast production. (3)

Further research is needed to fully understand the link between your bone health, osteocalcin, blood sugar, type 2 diabetes and obesity in humans. At present it appears that stimulating osteoblast growth is correlated with reducing unwanted weight gain.



Article Comments

Add New Comment

Your email address will not be published. Required fields are marked *

This article features advice from our industry experts to give you the best possible info through cutting-edge research.

Lara Pizzorno
MDiv, MA, LMT - Best-selling author of Healthy Bones Healthy You! and Your Bones; Editor of Longevity Medicine Review, and Senior Medical Editor for Integrative Medicine Advisors.,
Dr. Liz Lipski
PhD, CNS, FACN, IFMP, BCHN, LDN - Professor and Director of Academic Development, Nutrition programs in Clinical Nutrition at Maryland University of Integrative Health.,
Dr. Loren Fishman
MD, B.Phil.,(oxon.) - Medical Director of Manhattan Physical Medicine & Rehabilitation and Founder of the Yoga Injury Prevention Website.,
Prof. Didier Hans
PHD, MBA - Head of Research & Development Center of Bone Diseases, Lausanne University Hospital CHUV, Switzerland,